Name: CCQM meeting of the working groups CAWG, NAWG, and PAWG
Start: 2024-10-07T08:00:00+02:00
End: 2024-10-11T14:00:00+02:00
Location: PTB Berlin

Monday 7 October 2024

08:00 Registration on site
Registration on site
08:00 - 09:00
09:00 Session 1
Session 1
09:00 - 10:30
Room: Room 105
Contributions

09:00 Introductions (‘tour de table’ for those present, with online participants providing name and institution in the chat box). Agree agenda Agree minutes NAWG18– review action list - Jim Huggett all

09:30 General update on recent activities: K176, Good news stories - Jim Huggett (NML@LGC) all
1st Session - Miniworkshop
1st Session - Miniworkshop
09:00 - 10:30
Room: Room 510
Contributions

09:00 Welcome and introductions of participants - Claudia Swart (Physikalisch-Technische Bundesanstalt)

09:15 IDMS for proteins and peptides: historical development and approaches - G. O'Connor (PTB)

09:40 Insights from the use of solution calibrants from three metrology institutes for the measurement of urine albumin via IDMS - H. Tan (HSA)

10:05 Use of protein internal standard and its influence on the overall uncertainty - A. Green (NIST)
10:30 Coffee Break
Coffee Break
10:30 - 11:00
11:00 Session 2
Session 2
11:00 - 12:30
Room: Room 105
Contributions

11:00 CCQM-K189 INDEL/SNV - NIM

11:30 CCQM-K181/P227 SARS-CoV-2 RNA copy number quantification - NIM
2nd Session - Miniworkshop
2nd Session - Miniworkshop
11:00 - 12:30
Room: Room 510
Contributions

11:00 Quantification of troponin using protein or peptide-based calibrators - M. Öztug (TÜBITAK)

11:25 Calibration of RMPs with peptides Vs recombinant proteins: the example of procalcitonin and pTau - A. Boeuf (LNE) C. Giangrande (LNE)

11:50 Quantification of tHb in matrix with peptide and protein as calibrators: experience from CCQM P201 - Y. Liu (NIM)

12:15 Discussion and recommendations
12:30 Lunch Break
Lunch Break
12:30 - 13:30
13:30 Session 1
Session 1
13:30 - 15:30
Room: Room 305
Contributions

13:30 Welcome and register, Confirm/Appoint Rapporteur, Agree agenda, Review minutes and actions, Spring 2024 meeting - Julian Braybrook (NML@LGC)

14:00 P205 “Enumeration of membrane intact E.coli” - Boqiang Fu (NIM)

14:40 P197 “Proliferative stem cell number per unit area” - Nilofar Faruqui (NPL)

14:50 P222 “Particle enumeration for cellular analysis” - Yuki Kuruma (NMIJ)
Session 3
Session 3
13:30 - 15:30
Room: Room 105
Contributions

13:30 Orthogonal study - NMIA

14:30 SARS KC - NML@LGC

15:00 RNA Lipid Nanoparticles (LNPs) - NIST
3rd Session - Comparisons
3rd Session - Comparisons
13:30 - 15:30
Room: Room 510
Contributions

13:30 Follow-up investigations HbA1c - Q. Liu (HSA)

14:00 CMCs based on CCQM-K177 - C.-B. Arsene (PTB)

14:20 Update on CCQM K186/P238 - C. Brauckmann (PTB)

14:40 Update on CCQM K115d/P55.2d - G. Martos (BIPM)

15:00 Fire drill exercise - G. O'Connor (PTB) J. Melanson (NRC)
15:30 Coffee Break
Coffee Break
15:30 - 16:00
16:00 Session 2
Session 2
16:00 - 18:00
Room: Room 305
Contributions

16:00 P217 “Quantification of fixed mononuclear cells in suspension” - Deepa Rajagopal (NIST) Sumona Sarkar (NIST)

16:40 Assessment of current work programme; new Pilot studies, Key Comparison studies. Discussion - all
Session 4
Session 4
16:00 - 18:00
Room: Room 105
Contributions

16:00 CCQM NAWG Bio CMCs /Review

17:30 Food task group - INM
4th Session – Task groups
4th Session – Task groups
16:00 - 17:30
Room: Room 510
Contributions

16:00 Update task group on food - C. Portesi (INRIM)

16:20 Task group I - R. Josephs (BIPM)

16:40 Task group II - C.-B. Arsene (PTB)

17:00 Task group III - L. Wu (NIM) M. Ryadnov (NPL)

17:20 Closing for the day - Claudia Swart (PTB)
18:30

18:30 - 20:00
Tuesday 8 October 2024
09:00 Session 3
Session 3
09:00 - 10:30
Room: Room 305
Contributions

09:00 1) Review of CAWG Strategic plan and National needs identified at last meeting; identification of cell metrology opportunities - all
Session 5
Session 5
09:00 - 10:30
Room: Room 105
Contributions

09:00 CCQM-P231: Species specific meat composition determination of DNA extracted from meat - TÜBITAK
1st Session – scientific presentations
1st Session – scientific presentations
09:00 - 10:30
Room: Room 510
Contributions

09:00 Discovery of pharmabiotics from human gut microbiome - D. Kang (KRISS)

09:30 Absolute quantification of active protein by SPR and digital ELISA - L. Wu (NIM)

10:00 Structure related measurements - M. Ryadnov (NPL)
10:30 Coffee Break
Coffee Break
10:30 - 11:00
11:00 Session 4
Session 4
11:00 - 12:30
Room: Room 305
Contributions

11:00 2) Review of CAWG Strategic plan and National needs identified at last meeting; prioritization of cell metrology opportunities - all
Session 6
Session 6
11:00 - 12:30
Room: Room 105
Contributions

11:00 CCQM-P231: continued - TÜBITAK

11:30 CCQM-K86.d DNA Ratio in a High Protein Matrix - NIMT TÜBITAK

12:00 P232 Fire drill - NIST NML@LGC
2nd Session - scientific presentations and digitalisation
2nd Session - scientific presentations and digitalisation
11:00 - 12:30
Room: Room 510
Contributions

11:00 Characterization and Quantification of Monoclonal Antibodies by IDMS and ES-DMA-CPC - W. Mi (NIM)

11:30 Use of the digital expert - D. Hutzschenreuther (PTB)

12:15 Digitalization experience in protein measurement in NIM - L. Wu (NIM)
12:30 Lunch Break
Lunch Break
12:30 - 13:30
13:30 Session 5
Session 5
13:30 - 15:30
Room: Room 305
Contributions

13:30 3) Agreement on Next steps; Wrap-up - all
Session 7
Session 7
13:30 - 15:00
Room: Room 105
Contributions

13:30 Potential topics/Planned activities KCs/pilots - KRISS NIB
3rd Session - strategy
3rd Session - strategy
13:30 - 15:00
Room: Room 510
Contributions

13:30 Strategy - Claudia Swart (PTB) all

14:00 CMC Guidelines - Claudia Swart (PTB) all

14:30 Uncertainty evaluation issues - L. Wu (NIM) all
15:00 Coffee Break
Coffee Break
15:00 - 15:30
15:30 Session 8
Session 8
15:30 - 16:30
Room: Room 105
Contributions

15:30 Wrap up - all
4th Session - planning and other issues
4th Session - planning and other issues
15:30 - 16:45
Room: Room 510
Contributions

15:30 Planning of upcoming workshops - all

16:00 Update of VAMAS projects - M. Ryadnov (NPL)

16:15 Update of regional and NMIs’ metrology activities (ACRM,APMP......) - all

16:30 Other issues, wrap up and closing of the meeting - Claudia Swart (Physikalisch-Technische Bundesanstalt)
17:00 Transfer to the confernce dinner venue by public transport
Transfer to the confernce dinner venue by public transport
17:00 - 18:00

19:00 Boat trip
Boat trip
19:00 - 22:00
Wednesday 9 October 2024
09:00 Session 1
Session 1
09:00 - 10:30
Room: Observatorium
Contributions

09:00 Introductions (‘tour de table’ for those present, with online participants providing name and institution in the chat box). Agree agenda - WG Chairs

09:30 CAWG Update - Julian Braybrook (NML@LGC)
10:30 Coffee Break
Coffee Break
10:30 - 11:00
11:00 Session 2
Session 2
11:00 - 12:30
Room: Observatorium
Contributions

11:00 NAWG Update - Jim Huggett (NML@LGC)

11:45 PAWG Update - Claudia Swart (Physikalisch-Technische Bundesanstalt)
12:30 Lunch Break
Lunch Break
12:30 - 13:30
13:30 Session 3
Session 3
13:30 - 15:00
Room: Observatorium
Contributions

13:30 Joint workshops - Claudia Swart (Physikalisch-Technische Bundesanstalt)

14:00 WG support for RMOs, wider RMO interaction, Questionnaire - Mojca Milavec (NIB)

14:30 SOGATS (WHO comparisons) - Jim Huggett (NML@LGC)
15:00 Coffee Break
Coffee Break
15:00 - 15:30
15:30 Session 4
Session 4
15:30 - 17:30
Room: Observatorium
Contributions

15:30 Fire-drill update and wider pandemic TG - Julian Braybrook (NML@LGC)

15:55 Task group on units for bioanalysis - Jim Huggett (NML@LGC)

16:20 CCQM Task Group on Food Measurement

16:50 CCQM activities on Digital and FAIR Chemical and Biological Reference Data and Certificates: Challenges and Opportunities - Robert Wielgosz (BIPM)

17:10 Wrap up - WG Chairs
Thursday 10 October 2024

09:00 Welcome address
Welcome address
09:00 - 09:15
09:15 Session 1
Session 1
09:15 - 11:15
Room: Lecture Hall
Contributions

09:15 Quality assurance and standardization in molecular diagnostics of infections - Results from international IFCC surveys - Prof. Dr. Parviz Ahmad-Nejad (Helios Universitätsklinikum Wuppertal)

10:00 Ensuring accuracy in the development and application of bioanalytical diagnostic tests for infectious disease - Jim Huggett (NML@LGC)

10:50 Antimicrobial susceptibility testing of veterinary pathogen bacteria: possibility and needs - Heike Kaspar (BVL)
11:15 Session 2
Session 2
11:15 - 12:55
Room: Lecture Hall
Contributions

11:15 Protein reference material development for increased confidence in COVID-19 testing - Bradley Stocks (NRC)

11:40 Advanced molecular diagnostics for the detection of high risk pathogens: exploring new technologies for scalable, rapid, on-site pathogen detection - Andreas Puyskens (RKI)

12:05 Boosting Accuracy in Viral Load measurements with a Powerful Duo: Isotope Dilution Mass Spectrometry and Digital Droplet PCR - Yan Yan Beer (PTB)

12:30 Standardisation of Genome Amplification Techniques (SoGAT): current challenges in harmonising measurement for NAT based diagnostics - Neil Almond (MHRA)
12:55 Lunch break
Lunch break
12:55 - 13:40
13:40 Session 3
Session 3
13:40 - 15:20
Room: Lecture Hall
Contributions

13:40 Challenges in standardized pathogen identification and quantification in patient samples - Prof. Dr. Udo Reischl (INSTAND)

14:05 The challenges in preparation of control materials for small inter-laboratory comparisons: case studies of MPXV and Listeria monocytogenes - Alexandra Bogožalec Košir (NIB)

14:30 Reliable quantification of control samples for the virus genome detection to assess laboratory performance in EQA schemes - Annemarie Martin (GDB)

14:55 Synthetic Nucleic Acids as Reference Materials for Emerging Viruses - Megan Cleveland (NIST)
15:20 Final discussion
Final discussion
15:20 - 15:45
Room: Lecture Hall
Friday 11 October 2024
08:30 Transfer from PTB Charlottenburg and Visit at BAM and Beamline in Adlershof
Transfer from PTB Charlottenburg and Visit at BAM and Beamline in Adlershof
08:30 - 12:30
Contributions

08:30 Departure at PTB Berlin Charlottenburg, Bus transfer to Adlershof

10:00 Visit to BAM labs: Protein Analysis, Immunoanalysis/Molecular Biology, Biophotonics, Chemical and Optical Sensing

11:00 Visit to BESSY II Electron Storage Ring, PTB beamline, BAM line and Metrology Light Source (PTB)
12:30 Lunch break
Lunch break
12:30 - 13:30
Room: Berlin Adlershof